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New Blood Test Alzheimers

January 29, 2011

Voice of America reported January 22, 2011:

We’re looking for blood proteins that might be indicative of the extent of brain damage that we know occurs very early on in patients with Alzheimer’s disease,” said Thambisetty.

Dr. Thambisetty spearheaded a study that uses a blood test to detect the levels of a particular protein in the brain, beta-amyloid, that is thought to be a hallmark of the disease. Beta-amyloid is also present in spinal fluid of people with Alzheimer’s.

The common ways to detect Alzheimer’s disease are through brain scans using MRI (magnetic resonance imaging) or PET (positron emission tomography) scanning devices. These tests are expensive. Another method, taking a sample of a patient’s spinal fluid, is invasive. A blood test would be cheap and could be given widely to seemingly healthy people before the symptoms of Alzheimer’s set in.

In this particular study, researchers analyzed blood samples from 57 older volunteers who were symptom-free. They also measured the amyloid protein using PET scans. They found that those with high blood levels of the protein had significantly greater amounts of it in the part of the brain that controls memory.

Dr. Neil Buckholtz is chief of the dementias of aging branch of the National Institute on Aging. He says early intervention is key, as is learning how the brain changes before dementia sets in.

“Our hope is we will be able to identify the earliest changes that occur in the brain, how these changes progress over time, so that we’ll be able to target those for drug intervention, and again, eventually we’ll be able to slow the progression and, hopefully, stop the disease in its tracks,” said Buckholtz.

There’s a sense of urgency in the research to control the progression of Alzheimer’s disease because people the world over are living longer. That means more people, more caregivers, more families and more health care money will be impacted by this disease which already affects 20 million people worldwide.

“Recent studies suggest that the deposition of amyloid might happen several years before symptoms of memory impairment begin in somebody with Alzheimer’s disease,” added Thambisetty.

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